Biogenesis of Leishmania-harbouring vacuoles
نویسندگان
چکیده
Leishmania are protozoan parasites that cause several human diseases called leishmaniases, which can display very different clinical aspects (Peters and Killick-Kendrick, 1987b). The life cycle of Leishmania involves two kinds of hosts: dipteran insects (sandflies) and several mammals, in which they adopt a motile, flagellated, promastigote form and a non-motile, amastigote form with a very short flagellum, respectively (Peters and Killick-Kendrick, 1987a). The promastigotes colonize the lumen of the digestive tract of sandflies, where they multiply and differentiate into metacyclic promastigotes, which are infectious for mammals (Sacks, 1989). Metacyclic 2303
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